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Last updated: 2017/8/20
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CD209 monoclonal antibody, clone eB-h209

  • Catalog # : MAB10991
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against CD209.
  • Immunogen:
  • Human CD209.
  • Host:
  • Rat
  • Theoretical MW (kDa):
  • 44
  • Reactivity:
  • Human
  • Specificity:
  • The monoclonal antibody reacts with human CD209, a 44 kDa type II transmembrane protein.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In aqueous buffer (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunoprecipitation
  • Flow Cytometry
  • Flow Cytometry
  • Staining of human monocyte-derived immature dendritic cells with 0.5 ug of rat IgG2a kappa isotype control purified (open histogram) or 0.5 ug of CD209 monoclonal antibody, clone eB-h209 (Cat # MAB10991) (filled histogram) followed by Anti-rat IgG FITC. Cells in the large scatter population were used for analysis.
  • Application Image
  • Immunoprecipitation
  • Gene Information
  • Gene Name:
  • CD209
  • Gene Alias:
  • CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,MGC129965
  • Gene Description:
  • CD209 molecule
  • Gene Summary:
  • This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants
  • Other Designations:
  • C-type lectin domain family 4, member L,CD209 antigen,Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
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