Staining of CD3 + CD28 stimulated human PBMCs with Anti- human CD278 (ICOS) FITC (upper), and Anti-human CD278 (ICOS) PE (bottom). Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq