PSPH monoclonal antibody, clone 3G12
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant PSPH.
Immunogen
Recombinant protein corresponding to full length human PSPH.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Immunocytochemistry
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse brain tissue lysate.Immunocytochemistry
Immunofluorescence
Immunofluorescence analysis of A431 cells. The cell was stained with PSPH monoclonal antibody, clone 3G12 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PSPH
Entrez GeneID
5723GeneBank Accession#
NM_004577Protein Accession#
NP_004568Gene Name
PSPH
Gene Alias
PSP
Gene Description
phosphoserine phosphatase
Omim ID
172480Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq
Other Designations
L-3-phosphoserine phosphatase|O-phosphoserine phosphohydrolase|OTTHUMP00000025059|PSPase
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Interactome
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Pathway
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Publication Reference
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How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase.
Peeraer Y, Rabijns A, Collet JF, Van Schaftingen E, De Ranter C.
European Journal of Biochemistry 2004 Aug; 271(16):3421.
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Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.
Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY.
The Journal of Biological Chemistry 2002 Nov; 277(48):46651.
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Genetical and biochemical studies on human phosphoserine phosphatase.
Moro-Furlani AM, Turner VS, Hopkinson DA.
Annals of Human Genetics 1980 May; 43(4):323.
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How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase.
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