Staining of human TNFRSF10A-transfected cells with mouse IgG1 kappa isotype control purified (open histogram) or TNFRSF10A monoclonal antibody, clone DJR1 (Cat # MAB10907) (filled histogram) followed by Anti-mouse IgG FITC. Total viable cells were used for analysis.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq