Staining of normal human peripheral blood cells with 0.125 ug of mouse IgG1 kappa isotype control purified (open histogram) or 0.125 ug of TNFRSF14 monoclonal antibody, clone eBioHVEM-122 (Cat # MAB10904) (filled histogram) followed by Anti-mouse IgG biotin and streptavidin PE. Cells in the lymphocyte gate were used for analysis.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. [provided by RefSeq