Staining of normal human peripheral blood cells with 0.5 ug of mouse IgG2a kappa isotype control purified (open histogram) or 1.0 ug of TLR2 monoclonal antibody, clone TL2.3 (Cat # MAB10899) (filled histogram) followed by Anti-mouse IgG FITC. Cells in the monocyte gate were used for analysis.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq