Staining of TNFalpha-stimulated human Umbilical Vein Endothelial Cells (HUVEC) with 0.5 ug of mouse IgG1 kappa isotype control purified (open histogram) or 0.5 ug of SELE monoclonal antibody, clone P2H3 (Cat # MAB10896) (filled histogram) followed by F(ab')2 Anti-mouse IgG PE. Total viable cells were used for analysis.
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq