Staining of PANC-1 cell line with 0.125 ug of mouse IgG2a kappa isotype control purified (open histogram) or 0.125 ug of L1CAM monoclonal antibody, clone eBio5G3 (Cat # MAB10891) (filled histogram). Total viable cells were used for analysis.
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq
OTTHUMP00000025992,antigen identified by monoclonal antibody R1,neural cell adhesion molecule L1