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Last updated: 2016/11/27
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ITGB4 monoclonal antibody, clone 439-9B

  • Catalog # : MAB10889
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against ITGB4.
  • Immunogen:
  • Human ITGB4.
  • Host:
  • Rat
  • Theoretical MW (kDa):
  • 202
  • Reactivity:
  • Human
  • Specificity:
  • The monoclonal antibody recognizes human ITGB4, a 202 kDa subunit that associates with integrin alpha 6 (CD49f), thereby forming the laminin receptor. Multiple splice variants have been identified.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In aqueous buffer (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Flow Cytometry
  • Staining of the A-549 cell line with 0.5 ug of rat IgG2b kappa isotype control purified (open histogram) or 0.5 ug of ITGB4 monoclonal antibody, clone 439-9B (Cat # MAB10889) (filled histogram) followed by Anti-rat IgG biotin and streptavidin PE. Total viable cells were used for analysis.
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 3691
  • Gene Name:
  • ITGB4
  • Gene Alias:
  • CD104
  • Gene Description:
  • integrin, beta 4
  • Gene Summary:
  • Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • CD104 antigen,GP150,integrin beta 4,integrin beta-4 subunit
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