The monoclonal antibody reacts with human ITGB3, a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells.
The optimal working dilution should be determined by the end user.
In aqueous buffer (0.09% sodium azide)
Store at 4°C.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Staining of normal human peripheral blood platelets with 0.06 ug of mouse IgG1 kappa isotype control purified (upper) or 0.06 ug of ITGB3 monoclonal antibody, clone VI-PL2 (Cat # MAB10888) (bottom) followed by 'F(ab')2 Anti-mouse IgG PE followed by Anti-human CD42b FITC.
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq