Staining of normal human peripheral blood cells with 0.25 ug of mouse IgG1 kappa isotype control purified (open histogram) or 0.25 ug of ITGA5 monoclonal antibody, clone eBioSAM-1 (Cat # MAB10885) (filled histogram) followed by Anti-mouse IgG biotin and streptavidin PE. Cells in the lymphocyte gate were used for analysis.
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
fibronectin receptor, alpha subunit,integrin alpha 5,very late activation protein 5, alpha subunit