Staining of normal human peripheral blood cells with 0.25 ug of mouse IgG2b kappa isotype control purified (upper) or 0.25 ug of CXCR1 monoclonal antibody, clone eBio8F1-1-4 (Cat # MAB10882) (bottom) followed by F(ab')2 Anti-mouse IgG PE. Cells in the large scatter population were used for analysis.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq
receptor,alpha,interleukin-8 receptor type 1,interleukin-8 receptor type A