The monoclonal antibody reacts with human ICAM-2. ICAM-2 is a 55-65 kD transmembrane glycoprotein possessing 2 extracellular Ig domains, a single transmembrane domain, and a short 26-amino acid cytoplasmic domain.
The optimal working dilution should be determined by the end user.
In aqueous buffer (0.09% sodium azide)
Store at 4°C.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Staining of normal human peripheral blood cells with 0.06 ug of mouse IgG2a kappa isotype control purified (open histogram) or 0.06 ug of ICAM2 monoclonal antibody, clone CBRIC2/2 (Cat # MAB10880) (filled histogram) followed by F(ab')2 Anti-mouse IgG PE. Cells in the monocyte gate were used for analysis.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq