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Last updated: 2016/12/4
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CXCR2 monoclonal antibody, clone eBio5E8-C7-F10

  • Catalog # : MAB10878
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against CXCR2.
  • Immunogen:
  • Human CXCR2.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 67-70
  • Reactivity:
  • Human
  • Specificity:
  • The monoclonal antibody reacts with human CXCR2, a 67-70 kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In aqueous buffer (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Flow Cytometry
  • Flow Cytometry
  • Staining of normal human peripheral blood cells with 0.25 ug of mouse IgG1 kappa isotype control purified (upper) or 0.25 ug of CXCR2 monoclonal antibody, clone eBio5E8-C7-F10 (Cat # MAB10878) (bottom) followed by F(ab')2 Anti-mouse IgG PE. Cells in the large scatter population were used for analysis.
  • Application Image
  • Immunohistochemistry
  • Gene Information
  • Entrez GeneID:
  • 3579
  • Gene Name:
  • CXCR2
  • Gene Alias:
  • CD182,CDw128b,CMKAR2,IL8R2,IL8RA,IL8RB
  • Gene Description:
  • chemokine (C-X-C motif) receptor 2
  • Gene Summary:
  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq
  • Other Designations:
  • C-X-C chemokine receptor type 2,CXC-R2,CXCR-2,CXCR2 gene for IL8 receptor type B,GRO/MGSA receptor,IL-8 receptor type 2,IL-8R B,chemokine (CXC) receptor 2,high affinity interleukin-8 receptor B,interleukin 8 receptor B,interleukin 8 receptor type 2,interl
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