Staining of normal human peripheral blood cells with 0.5 ug of mouse IgG2b kappa isotype control Purifie (open histogram) or CD1D monoclonal antibody, clone 51.1 (Cat # MAB10857) (filled histogram) followed by Anti-mouse IgG biotin and streptavidin PE. Cells in the lymphocyte gate were used for analysis.
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. [provided by RefSeq
CD1D antigen,CD1D antigen, d polypeptide,HMC class I antigen-like glycoprotein CD1D,OTTHUMP00000024053,T-cell surface glycoprotein CD1d,differentiation antigen CD1-alpha-3,thymocyte antigen CD1D