Immunohistochemical analysis of paraffin-embedded human breast cancer (A) and lung cancer (B) tissues, showing nuclear localization using MSH2 monoclonal antibody, clone 3A2B8C (Cat # MAB10812) with DAB staining.
Confocal immunofluorescence analysis of HeLa cells using MSH2 monoclonal antibody, clone 1B3 (3A2B8C) (Cat # MAB10812) (green), showing nuclear localization. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. [provided by RefSeq