LMNA monoclonal antibody, clone 4E7
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis using LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790) against Raw264.7 (1), PC-12 (2), THP-1 (3), A-431 (4), MCF-7 (5) and Jurkat (6) cell lysate.
Western Blot (Recombinant protein)
Western blot analysis using LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790) against recombinant protein.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human striated muscle tissues using LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790) with DAB staining.
Enzyme-linked Immunoabsorbent Assay
ELISA measurement of LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant LMNA.
Immunogen
Recombinant protein corresponding to human LMNA.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790) against Raw264.7 (1), PC-12 (2), THP-1 (3), A-431 (4), MCF-7 (5) and Jurkat (6) cell lysate.Western Blot (Recombinant protein)
Western blot analysis using LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790) against recombinant protein.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human striated muscle tissues using LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790) with DAB staining.Enzyme-linked Immunoabsorbent Assay
ELISA measurement of LMNA monoclonal antibody, clone 4E7 (Cat # MAB10790). -
Gene Info — LMNA
Entrez GeneID
4000Gene Name
LMNA
Gene Alias
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Gene Description
lamin A/C
Gene Ontology
HyperlinkGene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
Other Designations
70 kDa lamin|OTTHUMP00000015843|OTTHUMP00000015848
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Interactome
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Pathway
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Disease
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