PARK7 monoclonal antibody, clone 1B11
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate was resolved by SDS - PAGE , transferred to PVDF membrane and probed with PARK7 monoclonal antibody , clone 1B11 (1 : 1000) (Cat # MAB1076) . Protein was visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system.
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant PARK7.
Immunogen
Recombinant protein corresponding to amino acids 1-189 of human PARK7.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate was resolved by SDS - PAGE , transferred to PVDF membrane and probed with PARK7 monoclonal antibody , clone 1B11 (1 : 1000) (Cat # MAB1076) . Protein was visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PARK7
Entrez GeneID
11315GeneBank Accession#
NM_007262Protein Accession#
NP_009193Gene Name
PARK7
Gene Alias
DJ-1, DJ1, FLJ27376, FLJ34360, FLJ92274
Gene Description
Parkinson disease (autosomal recessive, early onset) 7
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000001348|OTTHUMP00000001349|OTTHUMP00000001350|OTTHUMP00000001351|Parkinson disease protein 7|oncogene DJ1|protein DJ-1
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Interactome
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Disease
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Publication Reference
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Improved detection of prostate cancer using a magneto-nanosensor assay for serum circulating autoantibodies.
Xu L, Lee JR, Hao S, Ling XB, Brooks JD, Wang SX, Gambhir SS.
PLoS One 2019 Aug; 14(8):e0221051.
Application：Func, Det Ab, Human, Human serum.
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DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.
Zhou W, Freed CR.
The Journal of Biological Chemistry 2005 Dec; 280(52):43150.
Application：ICC, IF, WB, Rat, N27 cells, Rat primary dopamine neurons.
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Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.
Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM.
PNAS 2005 Jul; 102(27):9691.
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DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.
Meulener MC, Graves CL, Sampathu DM, Armstrong-Gold CE, Bonini NM, Giasson BI.
Journal of Neurochemistry 2005 Jun; 93(6):1524.
Application：IF, IHC-P, IP, WB-Re, Human, Human brain.
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Improved detection of prostate cancer using a magneto-nanosensor assay for serum circulating autoantibodies.
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