Immunofluorescence staining of CDX2 on COLO 320 HSR cells (positive) and WiDr cells (negative) using CDX2 monoclonal antibody, clone EPR2764Y (Cat # MAB10750) followed by Alexa Flour 488 conjugated donkey anti-rabbit IgG(H+L) as second antibody (Green) and DAPI for nucleus (Blue).
The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al., 1994 [PubMed 7698771]).[supplied by OMIM
OTTHUMP00000018176,caudal type homeo box transcription factor 2,caudal type homeobox transcription factor 2