Western blot analysis of mouse kidney (MK) and rat heart (RH) extracts were resolved by SDS - PAGE , transferred to PVDF membrane and probed with BMP7 monoclonal antibody , clone 4E7 (1 : 1000) (Cat # MAB1073) . Protein was visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq