BMP7 monoclonal antibody, clone 4E7
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of Lane 1: mouse kidney; Lane 2: rat heart lysate.
Immunocytochemistry
Immunocytochemistry analysis of HeLa cells. The cell was stained with BMP7 monoclonal antibody, clone 4E7 (Cat#MAB1073) (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant BMP7.
Immunogen
Recombinant protein corresponding to amino acids 293-431 of human BMP7.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Immunocytochemistry
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of Lane 1: mouse kidney; Lane 2: rat heart lysate.Immunocytochemistry
Immunocytochemistry analysis of HeLa cells. The cell was stained with BMP7 monoclonal antibody, clone 4E7 (Cat#MAB1073) (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — BMP7
Entrez GeneID
655GeneBank Accession#
NM_001719Protein Accession#
NP_001710Gene Name
BMP7
Gene Alias
OP-1
Gene Description
bone morphogenetic protein 7
Omim ID
112267Gene Ontology
HyperlinkGene Summary
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq
Other Designations
OTTHUMP00000031357|osteogenic protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix.
Gregory KE, Ono RN, Charbonneau NL, Kuo CL, Keene DR, Bachinger HP, Sakai LY.
The Journal of Biological Chemistry 2005 Jul; 280(30):27970.
Application：ELISA, WB, Human, 293 cells, Culture medium collected from 293 cells.
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Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.
Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Affolter M, Vale WW, Belmonte JC, Choe S.
Nature 2002 Dec; 420(6916):636.
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Regulation of BMP7 expression during kidney development.
Godin RE, Takaesu NT, Robertson EJ, Dudley AT.
Development 1998 Sep; 125(17):3473.
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The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix.
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