Immunohistochemical analysis of paraffin-embedded human lung cancer (upper) and cervical carcinoma (bottom) , showing nuclear localization using ISL1 monoclonal antibody, clone 1H9 (Cat # MAB10702) with DAB staining.
Confocal immunofluorescence analysis of HEK293 cells trasfected with full-length ISL1-hIgGFc using ISL1 monoclonal antibody, clone 1H9 (Cat # MAB10702) (green) . Blue: DRAQ5 fluorescent DNA dye.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq