Immunohistochemical analysis of paraffin-embedded human lymphoid (upper) , ovary tumor (middle) and testicle tumor (bottom) tissues using INHA monoclonal antibody, clone 4A2 (Cat # MAB10699) with DAB staining.
Confocal immunofluorescence analysis of HeLa cells using INHA monoclonal antibody, clone 4A2 (Cat # MAB10699) (green) . Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. [provided by RefSeq