Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues (upper) and rectum cancer tissues (bottom) using IGF1R monoclonal antibody, clone 3G5C1 (Cat # MAB10693) with DAB staining.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq