Immunohistochemical analysis of paraffin-embedded human colon cancer (upper) and ancreas cancer (bottom) , showing cytoplasmic localization using HCK monoclonal antibody, clone 3D12E10 (Cat # MAB10679) with DAB staining.
The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq