GCK monoclonal antibody, clone 4G6
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using GCK monoclonal antibody, clone 4G6 (Cat # MAB10666) against HEK293 (1) and GCK-hIgGFc transfected HEK293 (2) cell lysate.
Western Blot (Recombinant protein)
Western blot analysis using GCK monoclonal antibody, clone 4G6 (Cat # MAB10666) against recombinant protein.
Enzyme-linked Immunoabsorbent Assay
ELISA measurement of GCK monoclonal antibody, clone 4G6 (Cat # MAB10666) .
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant GCK.
Immunogen
Recombinant protein corresponding to human GCK.
Host
Mouse
Theoretical MW (kDa)
52
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using GCK monoclonal antibody, clone 4G6 (Cat # MAB10666) against HEK293 (1) and GCK-hIgGFc transfected HEK293 (2) cell lysate.Western Blot (Recombinant protein)
Western blot analysis using GCK monoclonal antibody, clone 4G6 (Cat # MAB10666) against recombinant protein.Enzyme-linked Immunoabsorbent Assay
ELISA measurement of GCK monoclonal antibody, clone 4G6 (Cat # MAB10666) . -
Gene Info — GCK
Entrez GeneID
2645Gene Name
GCK
Gene Alias
GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2
Gene Description
glucokinase (hexokinase 4)
Gene Ontology
HyperlinkGene Summary
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq
Other Designations
ATP:D-hexose 6-phosphotransferase|OTTHUMP00000024521|OTTHUMP00000159308|glucokinase|hexokinase D, pancreatic isozyme
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Interactome
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Pathway
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Disease
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