Immunohistochemical analysis of paraffin-embedded human cerebrum tumor (upper) , endothelium of vessel (middle) , lymphocyte of thymus (bottom) , showing cytoplasmic localization using FES monoclonal antibody, clone 2E3G3,2G9G1 (Cat # MAB10646) with DAB staining.
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms