SNCA monoclonal antibody, clone 5C2
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis of recombinant human alpha-synuclein protein.
Immunocytochemistry
Immunocytochemistry analysis of HeLa cells. The cell was stained with SNCA monoclonal antibody, clone 5C2 (Cat# MAB1064). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue)
-
Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant SNCA.
Immunogen
Recombinant protein corresponding to amino acids 61-95 of human SNCA.
Host
Mouse
Reactivity
Human
Specificity
This antibody has the specificity against the NAC domain of SNCA.
Form
Liquid
Purification
Protein A purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Immunocytochemistry
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Recombinant protein)
Western blot analysis of recombinant human alpha-synuclein protein.Immunocytochemistry
Immunocytochemistry analysis of HeLa cells. The cell was stained with SNCA monoclonal antibody, clone 5C2 (Cat# MAB1064). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue)Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
-
Gene Info — SNCA
Entrez GeneID
6622GeneBank Accession#
NM_000345Protein Accession#
NP_000336Gene Name
SNCA
Gene Alias
MGC110988, NACP, PARK1, PARK4, PD1
Gene Description
synuclein, alpha (non A4 component of amyloid precursor)
Gene Ontology
HyperlinkGene Summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161559|OTTHUMP00000161561|alpha synuclein|alpha-synuclein|alpha-synuclein, isoform NACP140|non A-beta component of AD amyloid|non A4 component of amyloid
-
Interactome
-
Disease
-
Publication Reference
-
Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid.
Paik SR, Lee JH, Kim DH, Chang CS, Kim J.
Archives of Biochemistry and Biophysics 1997 Aug; 344(2):325.
-
Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil.
Kim J.
Molecules and Cells 1997 Feb; 7(1):78.
-
Identification of two distinct synucleins from human brain.
Jakes R, Spillantini MG, Goedert M.
FEBS Letters 1994 May; 345(1):27.
Application：IHC-P, WB-Ti, Human, Human brains.
-
Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com