EPHB4 monoclonal antibody, clone 5B8F7
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant EPHB4.
Immunogen
Recombinant protein corresponding to human EPHB4.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2a
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using EPHB4 monoclonal antibody, clone 5B8F7 (Cat # MAB10636) against truncated EPHB4 recombinant protein.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human pancreas carcinoma (upper) and breast carcinoma (bottom) tissue, showing membrane and cytoplasmic (pancreas carcinoma) localization, membrane (breast carcinoma) localization using EPHB4 monoclonal antibody, clone 5B8F7 (Cat # MAB10636) with DAB staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — EPHB4
Entrez GeneID
2050Gene Name
EPHB4
Gene Alias
HTK, MYK1, TYRO11
Gene Description
EPH receptor B4
Omim ID
600011Gene Ontology
HyperlinkGene Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq
Other Designations
ephrin receptor EphB4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3
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Interactome
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Disease
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