Immunohistochemical analysis of paraffin-embedded human lung cancer (A) , colon cancer (B) , breast cancer (C) and rectal cancer (D) , using EPCAM monoclonal antibody, clone 7E11 (Cat # MAB10634) with DAB staining.
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq