Western blot analysis of human Ramos cell lysate (80 ug) were resolved by SDS - PAGE , transferred to PVDF membrane and probed with TLR7 monoclonal antibody , clone 4F4 (1 : 1000) (Cat # MAB1062). Proteins were visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system. Arrow indicates TLR7 protein in human Ramos cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq