Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues (upper) and submaxillary tumor tissues (bottom) using CREB1 monoclonal antibody, clone 5G3 (Cat # MAB10612) with DAB staining.
Immunofluorescence analysis of HeLa cells using CREB1 monoclonal antibody, clone 5G3 (Cat # MAB10612) (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
active transcription factor CREB,cAMP-response element-binding protein-1,transactivator protein