ERBB3 monoclonal antibody, clone 2F9
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using ERBB3 monoclonal antibody, clone 2F9 (Cat # MAB10585) against human ERBB3 (aa 22-369) -hIgGFc trasfected HEK293 cell lysate.
Immunofluorescence
Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ERBB3 (aa 22-369) -hIgGFc using ERBB3 monoclonal antibody, clone 2F9 (Cat # MAB10585) (green) . Blue: DRAQ5 fluorescent DNA dye.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant ERBB3.
Immunogen
Recombinant hIgGFc tag fusion protein corresponding to extracellular fragment at amino acids 22-369 of human ERBB3.
Host
Mouse
Theoretical MW (kDa)
148
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunofluorescence (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using ERBB3 monoclonal antibody, clone 2F9 (Cat # MAB10585) against human ERBB3 (aa 22-369) -hIgGFc trasfected HEK293 cell lysate.Immunofluorescence
Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ERBB3 (aa 22-369) -hIgGFc using ERBB3 monoclonal antibody, clone 2F9 (Cat # MAB10585) (green) . Blue: DRAQ5 fluorescent DNA dye.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ERBB3
Entrez GeneID
2065Gene Name
ERBB3
Gene Alias
ErbB-3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Gene Description
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq
Other Designations
erbB-3|lethal congenital contracture syndrome 2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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Interactome
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Pathway
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Disease
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