Immunoperoxidase staining using AKR1C2 monoclonal antibody, clone T101 (Cat # MAB10577) on formalin-fixed paraffin embedded human lung cancer tissue showing cytoplasmic localization of dihydrodiol dehydrogenase.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
OTTHUMP00000018995,OTTHUMP00000044759,aldo-keto reductase family 1, member C2,chlordecone reductase homolog,pseudo-chlordecone reductase,trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,type II dihydrodiol dehydrogenase