Western blot analysis using ADRBK1 monoclonal antibody, clone 3F8 (Cat # MAB10569) against HeLa (1), Jurkat (2), MOLT 4 (3), Raji (4), THP-1 (5), L1210 (6), COS-7 (7), PC-12 (8), and NIH/3T3 (9) cell lysate.
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq