Products

Western Blot (Cell lysate)

Western blot analysis using CHD3 monoclonal antibody, clone 2G4 (Cat # MAB10553) against HeLa (1), K-562 (2), Jurkat (3), NTERA-2 (4), HEK293 (5), Raji (6) cell lysate and mouse brain (7) tissue lysate.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using CHD3 monoclonal antibody, clone 2G4 (Cat # MAB10553) with DAB staining.

Immunofluorescence

Immunofluorescence analysis of HeLa cells using CHD3 monoclonal antibody, clone 2G4 (Cat # MAB10553) (green). Blue: DRAQ5 fluorescent DNA dye.

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Flow cytometric analysis of K-562 cells using CHD3 monoclonal antibody, clone 2G4 (Cat # MAB10553) (green) and negative control (purple).

Entrez GeneID

1107

Gene Name

CHD3

Gene Alias

Mi-2a, Mi2-ALPHA, ZFH

Gene Description

chromodomain helicase DNA binding protein 3

Omim ID

602120

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq

Other Designations

zinc-finger helicase (Snf2-like)