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Last updated: 2016/12/11
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CASP8 monoclonal antibody, clone 1H11

  • Catalog # : MAB10519
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant CASP8.
  • Immunogen:
  • Recombinant protein corresponding to human CASP8.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 26
  • Reactivity:
  • Human, Monkey, Mouse, Rat
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • ELISA (1:10000)
    Western Blot (1:500-1:2000)
    Immunohistochemistry (1:200-1:1000)
    Flow cytometry (1:200-1:400)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In ascites (0.03% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis using CASP8 monoclonal antibody, clone 1H11 (Cat # MAB10519) against HeLa (1), Jurkat (2), THP-1 (3), NIH/3T3 (4), COS-7 (5) and PC-12 (6) cell lysate.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human colon cancer (A) and human liver cancer (B) tissues using CASP8 monoclonal antibody, clone 1H11 (Cat # MAB10519) with DAB staining.
  • ELISA
  • ELISA
  • ELISA detection with CASP8 monoclonal antibody, clone 1H11 (Cat # MAB10519).
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of NIH/3T3 cells using CASP8 monoclonal antibody, clone 1H11 (Cat # MAB10519) (blue) and negative control (red).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 841
  • Gene Name:
  • CASP8
  • Gene Alias:
  • ALPS2B,CAP4,FLICE,FLJ17672,MACH,MCH5,MGC78473
  • Gene Description:
  • caspase 8, apoptosis-related cysteine peptidase
  • Gene Summary:
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq
  • Other Designations:
  • FADD-homologous ICE/CED-3-like protease,MACH-alpha-1/2/3 protein,MACH-beta-1/2/3/4 protein,Mch5 isoform alpha,OTTHUMP00000163718,OTTHUMP00000163719,OTTHUMP00000163720,caspase 8,caspase 8, apoptosis-related cysteine protease,cysteine protease,procaspase-8
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