Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues (A) and liver cancer tissues (B) using REL monoclonal antibody, clone 1E7 (Cat # MAB10516) with DAB staining.
Immunofluorescence analysis of U251 cells using REL monoclonal antibody, clone 1E7 (Cat # MAB10516) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM