Products

Western Blot (Transfected lysate)

Western blot analysis using BPTF monoclonal antibody, clone 2F10 (Cat # MAB10512) against HEK293 (1) and BPTF (aa : 503-670)-hIgGFc transfected HEK293 (2) cell lysate.

Enzyme-linked Immunoabsorbent Assay

ELISA detection with BPTF monoclonal antibody, clone 2F10 (Cat # MAB10512).

Entrez GeneID

2186

Gene Name

BPTF

Gene Alias

FAC1, FALZ, NURF301

Gene Description

bromodomain PHD finger transcription factor

Omim ID

601819

Gene Ontology

Hyperlink

Gene Summary

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq

Other Designations

bromodomain and PHD domain transcription factor|fetal Alz-50 reactive clone 1|fetal Alzheimer antigen|nucleosome remodeling factor, large subunit