Immunohistochemistry of human breast carcinoma tissues were incubated with TPD52L1 monoclonal antibody , clone d1C5 (1 : 200) (Cat # MAB1051) at room temperature. Slides were then washed in PBS , and were incubated in avidin biosystem anti - rabbit labeled polymer for 30 min at RT.
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined. [provided by RefSeq
OTTHUMP00000017133,OTTHUMP00000017135,OTTHUMP00000017136,tumor protein D52-like 2,tumor protein D53