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Last updated: 2017/11/19
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PPM1A monoclonal antibody, clone p6c7

  • Catalog # : MAB1050
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant PPM1A.
  • Immunogen:
  • Recombinant protein corresponding to full length human PPM1A.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Isotype:
  • IgG2b, kappa
  • Recommend Usage:
  • Western Blot (1:250-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • PPM1A monoclonal antibody, clone p6c7. Western blot analysis of PPM1 expression in human liver.
  • PDF DownloadProtocol Download
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Immunoblot analysis of mouse liver cytosol extract was resolved by electrophoresis , transferred to PVDF membrane and probed with PPM1A monoclonal antibody , clone p6c7 (1 : 250) (Cat # MAB1050) . Proteins were visualized using a goat anti - mouse secondary antibody conjugated to HRP and a DAP detection system. Arrow indicates PPM1A (~ 43 kDa) .
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • PPM1A monoclonal antibody, clone p6c7. Western blot analysis of PPM1 expression in Jurkat.
  • PDF DownloadProtocol Download
  • Immunoprecipitation
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunoprecipitation
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5494
  • Gene Name:
  • PPM1A
  • Gene Alias:
  • FLJ42306,MGC9201,PP2C-ALPHA,PP2CA
  • Gene Description:
  • protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
  • Gene Summary:
  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
  • Other Designations:
  • protein phosphatase 1A,protein phosphatase 2C alpha isoform
  • Gene Pathway
  • Related Disease
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