Western blot analysis using AXL monoclonal antibody, clone 7E10 (Cat # MAB10498) against extracellular domain of human AXL (aa 19-444).
Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using AXL monoclonal antibody, clone 7E10 (Cat # MAB10498)(green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq