Western blot analysis using ABCG2 monoclonal antibody, clone 1H2 (Cat # MAB10479) against HepG2 (1), COS-7 (2), Jurkat (3) and NIH/3T3 (4) cell lysate.
Immunofluorescence analysis of HeLa cells using ABCG2 monoclonal antibody, clone 1H2 (Cat # MAB10479) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq
ABC transporter,ATP-binding cassette transporter G2,ATP-binding cassette, sub-family G, member 2,breast cancer resistance protein,mitoxantrone resistance protein,placenta specific MDR protein