ABCG2 monoclonal antibody, clone 3G8
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) against NIH/3T3 (1) and COS-7 (2) cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues (A) and skeletal muscle tissues (B) using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) with DAB staining.
Immunofluorescence
Immunofluorescence analysis of HeLa cells using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Enzyme-linked Immunoabsorbent Assay
ELISA detection with ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478).
Flow Cytometry
Flow cytometric analysis of HepG2 cells using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) (green) and negative control (purple).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant ABCG2.
Immunogen
Recombinant protein corresponding to human ABCG2.
Host
Mouse
Theoretical MW (kDa)
72
Reactivity
Human, Monkey, Mouse
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
Immunofluorescence (1:200-1:1000)
Flow cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) against NIH/3T3 (1) and COS-7 (2) cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues (A) and skeletal muscle tissues (B) using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) with DAB staining.Immunofluorescence
Immunofluorescence analysis of HeLa cells using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.Enzyme-linked Immunoabsorbent Assay
ELISA detection with ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478).Flow Cytometry
Flow cytometric analysis of HepG2 cells using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) (green) and negative control (purple). -
Gene Info — ABCG2
Entrez GeneID
9429Gene Name
ABCG2
Gene Alias
ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, MGC102821, MRX, MXR, MXR1
Gene Description
ATP-binding cassette, sub-family G (WHITE), member 2
Omim ID
603756Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq
Other Designations
ABC transporter|ATP-binding cassette transporter G2|ATP-binding cassette, sub-family G, member 2|breast cancer resistance protein|mitoxantrone resistance protein|placenta specific MDR protein
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Interactome
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Pathway
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Disease
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