Immunohistochemical analysis of paraffin-embedded human brain (A) and breast carcinoma (B), showing cytoplasmic and membrane localization using PAWR monoclonal antibody, clone 3G9H7,4H12E9 (Cat # MAB10430) with DAB staining.
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq
WT1-interacting protein,prostate apoptosis response protein 4,prostate apoptosis response protein PAR-4,transcriptional repressor PAR4