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FGFR4 monoclonal antibody, clone 7H1

  • Catalog # : MAB10427
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant FGFR4.
  • Immunogen:
  • Recombinant protein corresponding to human FGFR4.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 87.9
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:500-1:2000)
    Immunofluorescence (1:200-1:1000)
    ELISA (1:10000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In ascitic (0.03% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • Western blot analysis using FGFR4 monoclonal antibody, clone 7H1 (Cat # MAB10427) against extracellular domain.
  • Immunofluorescence
  • Immunofluorescence
  • Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with FGFR4-hIgGFc using FGFR4 monoclonal antibody, clone 7H1 (Cat # MAB10427) (green), showing membrane localization. Blue: DRAQ5 fluorescent DNA dye.
  • ELISA
  • Application Image
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 2264
  • Gene Name:
  • FGFR4
  • Gene Alias:
  • CD334,JTK2,MGC20292,TKF
  • Gene Description:
  • fibroblast growth factor receptor 4
  • Gene Summary:
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000161430,hydroxyaryl-protein kinase,protein-tyrosine kinase,tyrosine kinase related to fibroblast growth factor receptor,tyrosylprotein kinase
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