SERPINE1 monoclonal antibody, clone 1D5
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) against HEK293 (1) and SERPINE1 (AA: 194-316)-hIgGFc transfected HEK293 (2) cell lysate.
Western Blot (Recombinant protein)
Western blot analysis using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) against human SERPINE1 (aa 194-316) recombinant protein. (Expected MW is 45kDa kDa)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung cancer (A) and human kidney cancer (B) tissue using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) with DAB staining.
Flow Cytometry
Flow cytometric analysis of NIH/3T3 cells using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant SERPINE1.
Immunogen
Recombinant protein corresponding to human SERPINE1.
Host
Mouse
Theoretical MW (kDa)
45
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
Flow cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) against HEK293 (1) and SERPINE1 (AA: 194-316)-hIgGFc transfected HEK293 (2) cell lysate.Western Blot (Recombinant protein)
Western blot analysis using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) against human SERPINE1 (aa 194-316) recombinant protein. (Expected MW is 45kDa kDa)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung cancer (A) and human kidney cancer (B) tissue using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) with DAB staining.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow cytometric analysis of NIH/3T3 cells using SERPINE1 monoclonal antobody, clone 1D5 (Cat # MAB10390) (green) and negative control (red). -
Gene Info — SERPINE1
Entrez GeneID
5054Gene Name
SERPINE1
Gene Alias
PAI, PAI-1, PAI1, PLANH1
Gene Description
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Omim ID
173360Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
plasminogen activator inhibitor, type I|plasminogen activator inhibitor-1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma.
Arroyo-Solera I, Pavón MÁ, León X, López M, Gallardo A, Céspedes MV, Casanova I, Pallarès V, López-Pousa A, Mangues MA, Barnadas A, Quer M, Mangues R.
Head & Neck 2019 Feb; 41(2):429.
Application：IF, IHC-P, Human, Mouse, Human head and neck squamous cell carcinoma, Mouse tongue.
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Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice via Increasing Levels of IL6R and PAI1.
Öner MG, Rokavec M, Kaller M, Bouznad N, Horst D, Kirchner T, Hermeking H.
Gastroenterology 2018 Aug; [Epub].
Application：IHC-P, Human, Colon carcinomas.
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Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma.
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