Western blot analysis using KARS monoclonal antibody, clone 8G12C1 (Cat # MAB10375) against truncated Trx-KARS recombinant protein (1), truncated MBP-KARS (aa 90-174) and full length KARS (aa 1-188) transfected CHO-K1 cell lysate (3).
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq