SORL1 monoclonal antibody, clone 7D7B11
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant SORL1.
Immunogen
Recombinant protein corresponding to amino acids 2159-2214 of human SORL1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis using SORL1 monoclonal antibody, clone 7D7B11 (Cat # MAB10367) against truncated SORL1 recombinant protein (1) and SORL1 (aa 2159-2214)-hIgGFc transfected CHO-K1 cell lysate (2).Enzyme-linked Immunoabsorbent Assay
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Gene Info — SORL1
Entrez GeneID
6653Gene Name
SORL1
Gene Alias
C11orf32, FLJ21930, FLJ39258, LR11, LRP9, SORLA, SorLA-1, gp250
Gene Description
sortilin-related receptor, L(DLR class) A repeats-containing
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. [provided by RefSeq
Other Designations
mosaic protein LR11|sortilin-related receptor containing LDLR class A repeats
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Interactome
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Disease
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