TNFRSF11B monoclonal antibody, clone 5A11
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using TNFRSF11B monoclonal antobody, clone 5A11 (Cat # MAB10336) against HEK293 (1) and TNFRSF11B-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human mammary cancer tissue (A) and lung cancer tissue (B) using TNFRSF11B monoclonal antobody, clone 5A11 (Cat # MAB10336) with DAB staining.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant TNFRSF11B.
Immunogen
Recombinant protein corresponding to human TNFRSF11B.
Host
Mouse
Theoretical MW (kDa)
60
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using TNFRSF11B monoclonal antobody, clone 5A11 (Cat # MAB10336) against HEK293 (1) and TNFRSF11B-hIgGFc transfected HEK293 (2) cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human mammary cancer tissue (A) and lung cancer tissue (B) using TNFRSF11B monoclonal antobody, clone 5A11 (Cat # MAB10336) with DAB staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TNFRSF11B
Entrez GeneID
4982Gene Name
TNFRSF11B
Gene Alias
MGC29565, OCIF, OPG, TR1
Gene Description
tumor necrosis factor receptor superfamily, member 11b
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq
Other Designations
osteoclastogenesis inhibitory factor|osteoprotegerin
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Interactome
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Pathway
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Disease
- Acute Disease
- Alveolar Bone Loss
- Alzheimer disease
- Arthritis
- Asthma
- Body Weight
- Bone Diseases
- Brain Ischemia
- Calcinosis
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