Products

Western Blot (Recombinant protein)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunofluorescence

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

Gene Name

SORL1

Gene Alias

C11orf32, FLJ21930, FLJ39258, LR11, LRP9, SORLA, SorLA-1, gp250

Gene Description

sortilin-related receptor, L(DLR class) A repeats-containing

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. [provided by RefSeq

Other Designations

mosaic protein LR11|sortilin-related receptor containing LDLR class A repeats